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Arch Biochem Biophys. 2017 Oct 15;632:209-221. doi: 10.1016/j.abb.2017.07.014. Epub 2017 Jul 25.

The UbiX-UbiD system: The biosynthesis and use of prenylated flavin (prFMN).

Author information

1
Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK.
2
Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK. Electronic address: david.leys@manchester.ac.uk.

Abstract

The UbiX-UbiD system consists of the flavin prenyltransferase UbiX that produces prenylated FMN that serves as the cofactor for the (de)carboxylase UbiD. Recent developments have provided structural insights into the mechanism of both enzymes, detailing unusual chemistry in each case. The proposed reversible 1,3-dipolar cycloaddition between the cofactor and substrate serves as a model to explain many of the key UbiD family features. However, considerable variation exists in the many branches of the UbiD family tree.

KEYWORDS:

(de)Carboxylase; Cycloaddition; Prenyl transferase; Prenylated FMN; UbiD; UbiX

PMID:
28754323
DOI:
10.1016/j.abb.2017.07.014
[Indexed for MEDLINE]

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