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Viruses. 2017 Jul 21;9(7). pii: E193. doi: 10.3390/v9070193.

Applicability of Metal Nanoparticles in the Detection and Monitoring of Hepatitis B Virus Infection.

Author information

1
Klinikum rechts der Isar, Technischen Universität München (TUM), Ismaniger Str. 22, 81675 Munich, Germany. maxim.shevtsov@tum.de.
2
Institute of Cytology of the Russian Academy of Sciences (RAS), Tikhoretsky Ave., 4, 194064 St. Petersburg, Russia. maxim.shevtsov@tum.de.
3
Institute of Virology, Technische Universität München/Helmholtz Zentrum München-German Center for Environmental Health, Trogerstr. 30, 81675 Munich, Germany. lili.zhao@tum.de.
4
Institute of Virology, Technische Universität München/Helmholtz Zentrum München-German Center for Environmental Health, Trogerstr. 30, 81675 Munich, Germany. protzer@tum.de.
5
Institute of Virology, Technische Universität München/Helmholtz Zentrum München-German Center for Environmental Health, Trogerstr. 30, 81675 Munich, Germany. maarten.van-de-klundert@tum.de.

Abstract

Chronic infection with the hepatitis B virus (HBV) can lead to liver failure and can cause liver cirrhosis and hepatocellular carcinoma (HCC). Reliable means for detecting and monitoring HBV infection are essential to identify patients in need of therapy and to prevent HBV transmission. Nanomaterials with defined electrical, optical, and mechanical properties have been developed to detect and quantify viral antigens. In this review, we discuss the challenges in applying nanoparticles to HBV antigen detection and in realizing the bio-analytical potential of such nanoparticles. We discuss recent developments in generating detection platforms based on gold and iron oxide nanoparticles. Such platforms increase biological material detection efficiency by the targeted capture and concentration of HBV antigens, but the unique properties of nanoparticles can also be exploited for direct, sensitive, and specific antigen detection. We discuss several studies that show that nanomaterial-based platforms enable ultrasensitive HBV antigen detection.

KEYWORDS:

biosensor; gold nanoparticles; hepatitis B; magnetic nanoparticles; virus

PMID:
28753992
PMCID:
PMC5537685
DOI:
10.3390/v9070193
[Indexed for MEDLINE]
Free PMC Article

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