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Mol Metab. 2017 Jun 19;6(8):809-818. doi: 10.1016/j.molmet.2017.06.007. eCollection 2017 Aug.

Angiopoietin-like 4 directs uptake of dietary fat away from adipose during fasting.

Author information

1
Department of Biochemistry, Fraternal Order of Eagles Diabetes Research Center, Obesity Research and Education Initiative, University of Iowa Carver College of Medicine, 169 Newton Rd, Iowa City, IA 52242, United States.
2
Department of Pharmacology and Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, 169 Newton Rd, Iowa City, IA 52242, United States.
3
Department of Biochemistry, Fraternal Order of Eagles Diabetes Research Center, Obesity Research and Education Initiative, University of Iowa Carver College of Medicine, 169 Newton Rd, Iowa City, IA 52242, United States. Electronic address: Brandon-davies@uiowa.edu.

Abstract

OBJECTIVE:

Angiopoietin-like 4 (ANGPTL4) is a fasting-induced inhibitor of lipoprotein lipase (LPL) and a regulator of plasma triglyceride metabolism. Here, we examined the kinetics of Angptl4 induction and tested the hypothesis that ANGPTL4 functions physiologically to reduce triglyceride delivery to adipose tissue during nutrient deprivation.

METHODS:

Gene expression, LPL activity, and triglyceride uptake were examined in fasted and fed wild-type and Angptl4-/- mice.

RESULTS:

Angptl4 was strongly induced early in fasting, and this induction was suppressed in mice with access to food during the light cycle. Fasted Angptl4-/- mice manifested increased LPL activity and triglyceride uptake in adipose tissue compared to wild-type mice.

CONCLUSIONS:

Angptl4 is induced early in fasting to divert uptake of fatty acids and triglycerides away from adipose tissues.

KEYWORDS:

ANGPTL4, angiopoietin-like 4; BAT, brown adipose tissue; GPIHBP1, glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1; LPL, lipoprotein lipase; Lipase inhibition; Lipolysis; Lipoprotein metabolism; Plasma triglycerides; gWAT, gonadal white adipose tissue; mWAT, mesenchymal white adipose tissue; sWAT, subcutaneous white adipose tissue

PMID:
28752045
PMCID:
PMC5518724
DOI:
10.1016/j.molmet.2017.06.007
[Indexed for MEDLINE]
Free PMC Article

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