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Nat Rev Cancer. 2017 Sep;17(9):528-542. doi: 10.1038/nrc.2017.53. Epub 2017 Jul 28.

Targeting autophagy in cancer.

Author information

1
Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.
2
Morgan Adams Foundation Pediatric Brain Tumor Research Program, Children's Hospital Colorado, Aurora, Colorado 80045, USA.
3
Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.

Abstract

Autophagy is a mechanism by which cellular material is delivered to lysosomes for degradation, leading to the basal turnover of cell components and providing energy and macromolecular precursors. Autophagy has opposing, context-dependent roles in cancer, and interventions to both stimulate and inhibit autophagy have been proposed as cancer therapies. This has led to the therapeutic targeting of autophagy in cancer to be sometimes viewed as controversial. In this Review, we suggest a way forwards for the effective targeting of autophagy by understanding the context-dependent roles of autophagy and by capitalizing on modern approaches to clinical trial design.

PMID:
28751651
PMCID:
PMC5975367
DOI:
10.1038/nrc.2017.53
[Indexed for MEDLINE]
Free PMC Article

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