Going viral? Linking the etiology of human prostate cancer to the PCA3 long noncoding RNA and oncogenic viruses

EMBO Mol Med. 2017 Oct;9(10):1327-1330. doi: 10.15252/emmm.201708072.

Abstract

The hypothesis is discussed that prostate cancer marker lncRNA PCA3 was introduced into the human genome by an oncogenic virus, and that viral infection‐related mechanisms might underlie its overexpression and prostate cancer initiation and/or progression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Neoplasm / genetics*
  • Base Sequence
  • Biomarkers, Tumor / genetics*
  • Computer Simulation
  • Humans
  • Male
  • Neoplasm Proteins / metabolism
  • Oncogenic Viruses / genetics*
  • Prostatic Neoplasms / genetics*
  • Prostatic Neoplasms / virology*
  • RNA, Long Noncoding / genetics*
  • Tumor Virus Infections / genetics

Substances

  • Antigens, Neoplasm
  • Biomarkers, Tumor
  • Neoplasm Proteins
  • PRUNE2 protein, human
  • RNA, Long Noncoding
  • prostate cancer antigen 3, human