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Environ Health. 2017 Jul 27;16(1):80. doi: 10.1186/s12940-017-0290-9.

Urinary bisphenol A and pubertal development in Chinese school-aged girls: a cross-sectional study.

Author information

1
Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, 779 Old Humin Road, Shanghai, 200237, China.
2
School of Public Health, Fudan University, Shanghai, 200032, China.
3
The National Centre for Register-based Research, Aarhus university, 8000, Aarhus, Denmark.
4
School of Public Health, Key Laboratory for Public Health Safety, Fudan University, Shanghai, 200032, China.
5
Department of Child and Adolescent Health, School of Public Health, Fudan University, Shanghai, 200032, China.
6
Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, 779 Old Humin Road, Shanghai, 200237, China. yuanwei11@yahoo.com.
7
Division of Research, Kaiser Foundation Research Institute, Kaiser Permanente, Oakland, CA, 94612, USA.

Abstract

BACKGROUND:

Animal studies suggest that bisphenol A (BPA) may perturb pubertal development in females. However, evidence from human studies is limited.

METHODS:

This was a cross-sectional study to investigate the association between BPA exposure and pubertal development in school-aged girls. A total of 655 girls aged 9-18 years were selected from three schools in Shanghai, from May to June 2011. We collected one single spot urine sample from each girl. Urine BPA concentrations were measured by modified high-performance liquid chromatography and categorized according to LOD and the median of those above LOD. Pubertal development status was assessed by using Tanner staging, and age at menarche was collected as a milestone for mid-puberty. Modified Poisson regression was used to estimate adjusted prevalence ratios (PRs) and 95% confidence intervals (CIs).

RESULTS:

After adjustment for potential confounders, girls with detected BPA were more likely to have delayed menarche, a mid-puberty event, compared with girls with undetectable BPA; the prevalence ratios (PR) were 0.73 (0.56, 0.95) for those with moderate BPA(LOD-median) and 0.72 (0.52, 0.99) for those with high BPA(>median), respectively. Girls aged 9-12 years with detected BPA were more likely to have reached pubic hair stage 2, the indicator of pubarche; while among girls aged >15 years, those with detected BPA were less likely to have reached pubic hair stage 5, the late stage of pubic hair development.

CONCLUSIONS:

BPA exposure was associated with alterations in the timing of pubertal development. Results in the present study should be interpreted with caution because of its cross-sectional nature and the limited sample size in each age group.

KEYWORDS:

Bisphenol A; Endocrine disruptor; Girl; Puberty; Tanner stage

PMID:
28750633
PMCID:
PMC5531012
DOI:
10.1186/s12940-017-0290-9
[Indexed for MEDLINE]
Free PMC Article

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