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Rev Med Chil. 2017 Apr;145(4):458-467. doi: 10.4067/S0034-98872017000400006.

[Sedentary lifestyle is associated with metabolic and cardiovascular risk factors independent of physical activity].

[Article in Spanish]

Author information

1
Instituto de Anatomía, Histología y Patología, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile.
2
Instituto de Farmacia, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile.
3
Grupo IRyS, Escuela de Educación Física, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile.
4
Departamento de Educación Física, Facultad de Educación, Universidad de Concepción, Concepción, Chile.
5
Departamento de Ciencias de la Actividad Física, Universidad de Los Lagos, Osorno, Chile.
6
Grupo de Investigación Calidad de Vida y Estilos de Vida Saludable, Universidad del Biobío, Chillán, Chile.
7
Departamento de Educación Física, Deportes y Recreación, Universidad de Temuco, Temuco, Chile.
8
Human Nutrition Research Centre, Institute of Cellular Medicine, University of Newcastle, Newcastle upon Tyne, United Kingdom.

Abstract

BACKGROUND:

Sedentary behavior is a main risk factor for cardiovascular disease and mortality.

AIM:

To investigate the association between sedentary behavior and metabolic and cardiovascular risk factors.

MATERIAL AND METHODS:

We assessed 322 participants aged between 18 to 65 years. Physical activity and sedentary behavior were measured with accelerometers (Actigraph®). Body mass index (BMI), waist circumference, percentage of body fat, diet and blood markers (glucose, lipid profile, insulin and HOMA-IR) were measured with standardized protocols.

RESULTS:

Thirty four percent of participants were physically inactive and spent on average 8.7 h/day on sedentary activities. Per one hour increase in sedentary behavior there were significant adverse changes in glucose (4.79 mg/dl), insulin (2.73 pmol/l), HOMA-IR (0.75), BMI (0.69 kg/m²), waist circumference (1.95 cm), fat mass (1.03%), total cholesterol (9.73 mg/dl), HDL-cholesterol (-3.50 mg/dl), LDL-cholesterol (10.7 mg/dl) and triglycerides (12.4 mg/dl). These findings were independent of main confounding factors including total physical activity, dietary factors, BMI and socio-demographics.

CONCLUSIONS:

The detrimental effect of sedentary behaviors on cardiometabolic and obesity-related traits is independent of physical activity levels. Therefore, reducing sedentary time should be targeted in the population apart from increasing their physical activity levels.

PMID:
28748993
DOI:
10.4067/S0034-98872017000400006
[Indexed for MEDLINE]
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