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Nihon Rinsho Meneki Gakkai Kaishi. 2017;40(3):155-159. doi: 10.2177/jsci.40.155.

Leptin and autoimmune disease.

[Article in Japanese]

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Department of Hematology and Clinical Immunology, Kanazawa Medical University.


Leptin is secreted from adipocytes and acts mainly on the hypothalamus causing weight loss due to suppression of appetite and increased energy expenditure. On the other hand, the leptin receptor is also expressed in hematopoietic cells and its action on the immune system has become known, and the significance of leptin in autoimmune diseases has gradually become clear. It has been shown that leptin acts as an exacerbating factor in many autoimmune diseases and it is suggested that inhibition of leptin signal may be a novel therapeutic method for autoimmune diseases. In this article, we will outline the significance of leptin in the immune system based on the current reports.


autoimmune disease; leptin; rheumatoid arthritis; systemic lupus erhthematosus

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