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Open Biol. 2017 Jul;7(7). pii: 170121. doi: 10.1098/rsob.170121.

lncRNAs in development and disease: from functions to mechanisms.

Author information

1
Watson School of Biological Sciences, Cold Spring Harbor Laboratory, New York, NY 11724, USA.
2
Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge CB2 0RE, UK.
3
Watson School of Biological Sciences, Cold Spring Harbor Laboratory, New York, NY 11724, USA greg.hannon@cruk.cam.ac.uk.
4
New York Genome Center, 101 6th Ave, New York, NY 10013, USA.

Abstract

Differential expression of long non-coding RNAs (lncRNAs) during differentiation and their misregulation in cancer highlight their potential as cell fate regulators. While some example lncRNAs have been characterized in great detail, the functional in vivo relevance of others has been called into question. Finding functional lncRNAs will most probably require a combination of complementary approaches that will greatly vary depending on their mode of action. In this review, we discuss the different tools available to dissect genetically lncRNA requirements and how each is best suited to studies in particular contexts. Moreover, we review different strategies used to select candidate lncRNAs and give an overview of lncRNAs described to regulate development and cancer through different mechanisms.

KEYWORDS:

cancer; development; long non-coding RNAs

PMID:
28747406
PMCID:
PMC5541349
DOI:
10.1098/rsob.170121
[Indexed for MEDLINE]
Free PMC Article

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