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J Transl Med. 2017 Jul 26;15(1):162. doi: 10.1186/s12967-017-1263-z.

The European ME/CFS Biomarker Landscape project: an initiative of the European network EUROMENE.

Author information

1
Institute for Medical Immunology, Charité-Universitätsmedizin Berlin, Campus Virchow, Augustenburger Platz 1/Sudstrasse 2, 13353, Berlin, Germany. carmen.Scheibenbogen@charite.de.
2
Institute for Medical Immunology, Charité-Universitätsmedizin Berlin, Campus Virchow, Augustenburger Platz 1/Sudstrasse 2, 13353, Berlin, Germany.
3
Institut de Recerca de la Sida IrsiCaixa-HIVACAT, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, IGTP, UAB, Carretera del Canyet, s/n, 08916, Badalona, Spain.
4
Universitat de Vic-UCC, Carrer de la Sagrada Família, 7, 08500 Vic, Barcelona, Spain.
5
Deptartment of Earth and Environmental Sciences, University of Pavia, Via Ferrata 7, 27100, Pavia, Italy.
6
Centre for Health Technologies (CHT), University of Pavia, Via Ferrata 5, 27100, Pavia, Italy.
7
Clinical Research Department, Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel St, Bloomsbury, London, WC1E 7HT, UK.
8
Faculty of Medicine, Paris Est-Creteil University, 8 rue du General Sarrail, 94000, Creteil, France.
9
Pain in Motion International Research Group, Brussels, Belgium.
10
Department of Rehabilitation Sciences and Physiotherapy, Faculty of Medicine and Health Sciences, Ghent University, St. Pietersnieuwstraat 33, 9000, Ghent, Belgium.
11
Department of Rehabilitation Sciences and Physiotherapy (MOVANT), Faculty of Medicine and Health Sciences, University of Antwerp, Prinsstraat 13, 2000, Antwerp, Belgium.
12
Vall d'Hebron University Hospital, CFS/ME Unit, Universitat Autònoma de Barcelona, 119-129, Passeig de la Vall d'Hebron, 08035, Barcelona, Spain.
13
August Kirchenstein Institute of Microbiology and Virology, Riga Stradins University, Dzirciema iela 16, Kurzemes rajons, Rīga, 1007, Latvia.
14
Facultad de Medicina, Universidad Católica de Valencia, San Vicente Mártir, Carrer de Quevedo, 2, 46001, Valencia, Spain.
15
Instituto Valenciano de Patología (IVP) de la Universidad Católica de Valencia San Vicente Mártir, Centro de Investigación Príncipe Felipe (CIPF), Carrer d'Eduardo Primo Yúfera, 3, 46012, Valencia, Spain.
16
Division of Medicine, CFS/ME Center, Oslo University Hospital, Aker, Trondheimsveien 235, 0586, Oslo, Norway.
17
Department of Paediatrics, Norwegian National Advisory Unit on CFS/ME, Rikshospitalet, Sognsvannsveien 20, 0372, Oslo, Norway.
18
Department of Virology, National Center of Infectious and Parasitic Diseases, 44A General Stoletov blvd., 1233, Sofia, Bulgaria.
19
Department of Neurology, Medical Faculty Novi Sad, Hajduk Veljkova 3, 21000, Novi Sad, Serbia.

Abstract

Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) is a common and severe disease with a considerable social and economic impact. So far, the etiology is not known, and neither a diagnostic marker nor licensed treatments are available yet. The EUROMENE network of European researchers and clinicians aims to promote cooperation and advance research on ME/CFS. To improve diagnosis and facilitate the analysis of clinical trials surrogate markers are urgently needed. As a first step for developing such biomarkers for clinical use a database of active biomarker research in Europe was established called the ME/CFS EUROMENE Biomarker Landscape project and the results are presented in this review. Further we suggest strategies to improve biomarker development and encourage researchers to take these into consideration for designing and reporting biomarker studies.

KEYWORDS:

Autoantibodies; Autoimmunity; B cell; Biomarker; Cytokines; Diagnostic; European network; Landscape project; ME/CFS; Viral

PMID:
28747192
PMCID:
PMC5530475
DOI:
10.1186/s12967-017-1263-z
[Indexed for MEDLINE]
Free PMC Article

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