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J Med Primatol. 2017 Dec;46(6):293-303. doi: 10.1111/jmp.12290. Epub 2017 Jul 26.

Effect of moderate, 30 percent global maternal nutrient reduction on fetal and postnatal baboon phenotype.

Author information

1
Texas Pregnancy and Life-course Health Center, Department of Animal Sciences, University of Wyoming, Laramie, WY, USA.
2
Texas Biomedical Research Institute, San Antonio, TX, USA.

Abstract

BACKGROUND:

Most developmental programming studies on maternal nutrient reduction (MNR) are in altricial rodents whose maternal nutritional burden and offspring developmental trajectory differ from precocial non-human primates and humans.

METHODS:

Control (CTR) baboon mothers ate ad libitum; MNR mothers ate 70% global control diet in pregnancy and lactation.

RESULTS:

We present offspring morphometry, blood cortisol, and adrenocorticotropin (ACTH) during second half of gestation (G) and first three postnatal years. Moderate MNR produced intrauterine growth restriction (IUGR). IUGR males (n=43) and females (n=28) were smaller than CTR males (n=50) and females (n=47) in many measurements at many ages. In CTR, fetal ACTH increased 228% and cortisol 48% between 0.65G and 0.9G. IUGR ACTH was elevated at 0.65G and cortisol at 0.9G. 0.9G maternal gestational weight gain, fetal weight, and placenta weight were correlated.

CONCLUSIONS:

Moderate IUGR decreased body weight and morphometric measurements at key time points and altered hypothalamo-pituitary-adrenal function.

KEYWORDS:

Papio ; cortisol; developmental programming; intrauterine growth restriction; maternal nutrition; non-human primates

PMID:
28744866
PMCID:
PMC5673574
DOI:
10.1111/jmp.12290
[Indexed for MEDLINE]
Free PMC Article

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