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Toxicol Res. 2017 Jul;33(3):233-238. doi: 10.5487/TR.2017.33.3.233. Epub 2017 Jul 15.

Xylene Induces Oxidative Stress and Mitochondria Damage in Isolated Human Lymphocytes.

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Department of Pharmacology and Toxicology, School of Pharmacy, Ardabil University of Medical Science, Ardabil, Iran.
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


Xylene is a cyclic hydrocarbon and an environmental pollutant. It is also used in medical technology, paints, dyes, polishes and in many industries as a solvent; therefore, an understanding of the interaction between xylene and human lymphocytes is of significant interest. Biochemical assessment was used to demonstrate that exposure of lymphocytes to xylene induces cytotoxicity (at 6 hr), generates intracellular reactive oxygen species, collapse of mitochondrial membrane potential, lysosomal injury, lipid peroxidation and depletion of glutathione (at 3 hr). The findings show that xylene triggers oxidative stress and organelle damage in lymphocytes. The results of our study suggest that the use of antioxidant, mitochondrial and lysosomal protective agents can be helpful for individuals subject to chronic exposure to xylene.


Cytotoxicity; Lymphocyte; Mitochondrial damage; Oxidative stress; Xylene

Conflict of interest statement

CONFLICT OF INTEREST All authors declare that they have no conflict of interest.

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