Format

Send to

Choose Destination
Environ Res. 2017 Oct;158:737-747. doi: 10.1016/j.envres.2017.07.023. Epub 2017 Jul 22.

Prenatal exposure to organophosphorus pesticides and childhood neurodevelopmental phenotypes.

Author information

1
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, United States. Electronic address: mfurlong@email.arizona.edu.
2
Department of Statistical Science and Global Health Institute, Duke University, United States.
3
Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, United States.
4
Department of Psychology and Neuroscience & FPG Child Development Institute, University of North Carolina at Chapel Hill, United States.
5
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, United States.
6
Department of Environmental Medicine and Public Health, Mount Sinai School of Medicine, United States.
7
Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, United States.
8
Department of Environmental Health, Rollins School of Public Health, Emory University, United States.

Abstract

Prenatal exposure to organophosphorus pesticides (OPs) has been associated with different neurodevelopmental outcomes across different cohorts. A phenotypic approach may address some of these differences by incorporating information across scales and accounting for the complex correlational structure of neurodevelopmental outcomes. Additionally, Bayesian hierarchical modeling can account for confounding by collinear co-exposures. We use this framework to examine associations between prenatal exposure to OPs and behavior, executive functioning, and IQ assessed at age 6-9 years in a cohort of 404 mother/infant pairs recruited during pregnancy. We derived phenotypes of neurodevelopment with a factor analysis, and estimated associations between OP metabolites and these phenotypes in Bayesian hierarchical models for exposure mixtures. We report seven factors: 1) Impulsivity and Externalizing, 2) Executive Functioning, 3) Internalizing, 4) Perceptual Reasoning, 5) Adaptability, 6) Processing Speed, and 7) Verbal Intelligence. These, along with the Working Memory Index, were standardized and scaled so that positive values reflected positive attributes and negative values represented adverse outcomes. Standardized dimethylphosphate metabolites were negatively associated with Internalizing factor scores (β^ - 0.13, 95% CI - 0.26, 0.00) but positively associated with Executive Functioning factor scores (β^ 0.18, 95% CI 0.04, 0.31). Standardized diethylphosphate metabolites were negatively associated with the Working Memory Index (β^ - 0.17, 95% CI - 0.33, - 0.03). Associations with factor scores were generally stronger and more precise than associations with individual instrument-specific items. Factor analysis of outcomes may provide some advantages in etiological studies of childhood neurodevelopment by incorporating information across scales to reduce dimensionality and improve precision.

PMID:
28743040
PMCID:
PMC5577985
DOI:
10.1016/j.envres.2017.07.023
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center