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Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):8528-8531. doi: 10.1073/pnas.1703995114. Epub 2017 Jul 24.

Salate derivatives found in sunscreens block experimental autoimmune encephalomyelitis in mice.

Author information

1
Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706.
2
Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706 deluca@biochem.wisc.edu.

Abstract

UV light suppresses experimental autoimmune encephalomyelitis (EAE), a widely used animal model of MS, in mice and may be responsible for the decreased incidence of MS in equatorial regions. To test this concept further, we applied commercially available sunblock preparations to mice before exposing them to UV radiation. Surprisingly, some of the sunblock preparations blocked EAE without UV radiation. Furthermore, various sunblock preparations had variable ability to suppress EAE. By examining the components of the most effective agents, we identified homosalate and octisalate as the components responsible for suppressing EAE. Thus, salates may be useful in stopping the progression of MS, and may provide new insight into mechanisms of controlling autoimmune disease.

KEYWORDS:

experimental autoimune encephalomyelitis; homosalate; multiple sclerosis; octisalate; sunscreen

PMID:
28739922
PMCID:
PMC5559021
DOI:
10.1073/pnas.1703995114
[Indexed for MEDLINE]
Free PMC Article

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