Format

Send to

Choose Destination
Anticancer Res. 2017 Aug;37(8):4605-4610.

Explored Risk Factors for Lymph Node Metastasis with Siewert II/III Adenocarcinoma of the Gastroesophageal Junction.

Author information

1
Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Cancer Invasion and Metastasis Research, National Clinical Research Center for Digestive Diseases, Beijing, P.R. China.
2
Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Cancer Invasion and Metastasis Research, National Clinical Research Center for Digestive Diseases, Beijing, P.R. China zhangjundoctor@163.com.

Abstract

AIM:

To explore the risk factors and prognosis for lymphatic metastasis (LNM) in patients with Siewert II/III adenocarcinoma of the gastroesophageal junction (AEG).

PATIENTS AND METHODS:

This study retrospectively reviewed 49 patients with Siewert II/III AEG. Clinical characteristics and pathological features were analyzed by the Chi-square the and binary logistic regression. Survival data were analyzed using the Kaplan-Meier method.

RESULTS:

LNM frequency was found in lymph nodes No.1, No.2, No.3, No.7, No.11 and No.110. The results revealed that depth of infiltration, neoplasms by histological type and lymphatic embolus were independent risk factors for LNM. The 1- and 3-year survival of patients without LNM were both 100%, while patients with LNM had 70% and 60% survival, respectively. Although the differences were not statistically significant, survival rate with negative lymph nodes was higher than in patients with LNM.

CONCLUSION:

Total gastrectomy combined with D2 No.110 lymphadenectomy might improve the prognosis for LNM patients.

KEYWORDS:

Adenocarcinoma of the gastroesophageal junction; Siewert II/III; logistic regression analysis; lymphatic metastasis; univariate analysis

PMID:
28739759
DOI:
10.21873/anticanres.11860
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center