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Allergol Immunopathol (Madr). 2018 May - Jun;46(3):253-262. doi: 10.1016/j.aller.2017.05.003. Epub 2017 Jul 22.

Component-resolved diagnosis in hymenoptera allergy.

Author information

1
Servicio de Enfermedades del Sistema Inmune-Alergia, Hospital Universitario Principe de Asturias, Departamento de Medicina, Universidad de Alcalá, Madrid, Spain. Electronic address: dario.antolin@gmail.com.
2
Servicio de Alergología, Hospital Universitario Reina Sofía, Maimonides Biomedical Research Institute of Córdoba (IMIBIC), Córdoba, Spain.
3
S.S. Allergologia, ASL Alessandria, Hospital Santo Spirito, Casale Monferrato (AL), Italy.
4
Servicio de Alergología, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain.
5
Servicio de Enfermedades del Sistema Inmune-Alergia, Hospital Universitario Príncipe de Asturias, Departamento de Medicina, Universidad de Alcalá, Madrid, Spain.
6
Servicio de Alergología, Hospital Universitario Ramón y Cajal, Madrid, Spain.
7
Servicio de Alergología, Hospital Clínico San Carlos, Madrid, Spain.
8
Servicio de Alergología, Hospital Universitario de Guadalajara, Guadalajara, Spain.

Abstract

Component-resolved diagnosis based on the use of well-defined, properly characterised and purified natural and recombinant allergens constitutes a new approach in the diagnosis of venom allergy. Prospective readers may benefit from an up-to-date review on the allergens. The best characterised venom is that of Apis mellifera, whose main allergens are phospholipase A2 (Api m1), hyaluronidase (Api m2) and melittin (Api m4). Additionally, in recent years, new allergens of Vespula vulgaris have been identified and include phospholipase A1 (Ves v1), hyaluronidase (Ves v2) and antigen 5 (Ves v5). Polistes species are becoming an increasing cause of allergy in Europe, although only few allergens have been identified in this venom. In this review, we evaluate the current knowledge about molecular diagnosis in hymenoptera venom allergy.

KEYWORDS:

Allergy; Anaphylaxis; Apis; Component resolved diagnosis; Cross-reactivity; Hymenoptera; Insect stings; Polistes; Vespula

PMID:
28739022
DOI:
10.1016/j.aller.2017.05.003
[Indexed for MEDLINE]

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