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Hum Genomics. 2017 Jul 24;11(1):17. doi: 10.1186/s40246-017-0113-7.

Long non-coding RNAs as novel players in β cell function and type 1 diabetes.

Mirza AH1,2,3, Kaur S1, Pociot F4,5,6.

Author information

1
CPH-DIRECT, Department of Pediatrics, Herlev University Hospital, Herlev Ringvej 75, DK-2730, Herlev, Denmark.
2
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
3
Center for non-coding RNA in Technology and Health, University of Copenhagen, Copenhagen, Denmark.
4
CPH-DIRECT, Department of Pediatrics, Herlev University Hospital, Herlev Ringvej 75, DK-2730, Herlev, Denmark. flemming.pociot.01@regionh.dk.
5
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. flemming.pociot.01@regionh.dk.
6
Center for non-coding RNA in Technology and Health, University of Copenhagen, Copenhagen, Denmark. flemming.pociot.01@regionh.dk.

Abstract

BACKGROUND:

Long non-coding RNAs (lncRNAs) are a sub-class within non-coding RNA repertoire that have emerged as crucial regulators of the gene expression in various pathophysiological conditions. lncRNAs display remarkable versatility and wield their functions through interactions with RNA, DNA, or proteins. Accumulating body of evidence based on multitude studies has highlighted the role of lncRNAs in many autoimmune and inflammatory diseases, including type 1 diabetes (T1D). This review highlights emerging roles of lncRNAs in immune and islet β cell function as well as some of the challenges and opportunities in understanding the pathogenesis of T1D and its complications.

CONCLUSION:

We accentuate that the lncRNAs within T1D-loci regions in consort with regulatory variants and enhancer clusters orchestrate the chromatin remodeling in β cells and thereby act as cis/trans-regulatory determinants of islet cell transcriptional programs.

KEYWORDS:

3D genome architecture; Enhancers; Long non-coding RNAs; Regulatory elements; Type 1 diabetes

PMID:
28738846
PMCID:
PMC5525349
DOI:
10.1186/s40246-017-0113-7
[Indexed for MEDLINE]
Free PMC Article

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