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ACS Nano. 2017 Aug 22;11(8):8103-8113. doi: 10.1021/acsnano.7b02918. Epub 2017 Jul 28.

Photothermal Effect Enhanced Cascade-Targeting Strategy for Improved Pancreatic Cancer Therapy by Gold Nanoshell@Mesoporous Silica Nanorod.

Zhao R1,2,3, Han X1,2,3, Li Y1,3, Wang H1,3, Ji T1,4, Zhao Y1,3, Nie G1,3.

Author information

1
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center of Excellence in Nanoscience, National Center for Nanoscience and Technology , Beijing 100190, P. R. China.
2
Department of Chemistry, Tsinghua University , Beijing 100084, P. R. China.
3
University of Chinese Academy of Sciences , Beijing 100049, P. R. China.
4
Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Children's Hospital Boston, Harvard Medical School , 300 Longwood Avenue, Boston, Massachusetts 02115, United States.

Abstract

Pancreatic cancer, one of the leading causes of cancer-related mortality, is characterized by desmoplasia and hypovascular cancerous tissue, with a 5 year survival rate of <8%. To overcome the severe resistance of pancreatic cancer to conventional therapies, we synthesized gold nanoshell-coated rod-like mesoporous silica (GNRS) nanoparticles which integrated cascade tumor targeting (mediated by photothermal effect and molecular receptor binding) and photothermal treatment-enhanced gemcitabine chemotherapy, under mild near-infrared laser irradiation condition. GNRS significantly improved gemcitabine penetration and accumulation in tumor tissues, thus destroying the dense stroma barrier of pancreatic cancer and reinforcing chemosensitivity in mice. Our current findings strongly support the notion that further development of this integrated plasmonic photothermal strategy may represent a promising translational nanoformulation for effective treatment of pancreatic cancer with integral cascade tumor targeting strategy and enhanced drug delivery efficacy.

KEYWORDS:

chemotherapeutic sensitivity; combination therapy; gold nanoshell; pancreatic cancer; photothermal effect; tumor targeting

PMID:
28738680
DOI:
10.1021/acsnano.7b02918

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