Format

Send to

Choose Destination
Sci Immunol. 2017 Apr 14;2(10). pii: eaam6346. doi: 10.1126/sciimmunol.aam6346.

Resident memory T cells in the skin mediate durable immunity to melanoma.

Author information

1
Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
2
Parker Institute for Cancer Immunotherapy and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
3
Departments of Microbiology and Immunology, and Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.
4
Department of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA.
5
Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA.
6
Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA. mary.jo.turk@dartmouth.edu.

Abstract

Tissue-resident memory T (TRM) cells have been widely characterized in infectious disease settings; however, their role in mediating immunity to cancer remains unknown. We report that skin-resident memory T cell responses to melanoma are generated naturally as a result of autoimmune vitiligo. Melanoma antigen-specific TRM cells resided predominantly in melanocyte-depleted hair follicles and were maintained without recirculation or replenishment from the lymphoid compartment. These cells expressed CD103, CD69, and CLA (cutaneous lymphocyte antigen), but lacked PD-1 (programmed cell death protein-1) or LAG-3 (lymphocyte activation gene-3), and were capable of making IFN-γ (interferon-γ). CD103 expression on CD8 T cells was required for the establishment of TRM cells in the skin but was dispensable for vitiligo development. CD103+ CD8 TRM cells were critical for protection against melanoma rechallenge. This work establishes that CD103-dependent TRM cells play a key role in perpetuating antitumor immunity.

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center