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J Am Chem Soc. 2017 Aug 16;139(32):10992-10995. doi: 10.1021/jacs.7b05559. Epub 2017 Aug 3.

Continuous O2-Evolving MnFe2O4 Nanoparticle-Anchored Mesoporous Silica Nanoparticles for Efficient Photodynamic Therapy in Hypoxic Cancer.

Kim J1,2, Cho HR1,3, Jeon H1,3, Kim D1,2, Song C1,2, Lee N4, Choi SH1,3, Hyeon T1,2.

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Center for Nanoparticle Research, Institute of Basic Science (IBS) , Seoul 08826, Republic of Korea.
School of Chemical and Biological Engineering, and Institute of Chemical Processes, Seoul National University , Seoul 08826, Republic of Korea.
Department of Radiology, Seoul National University College of Medicine , Seoul 03080, Republic of Korea.
School of Advanced Materials Engineering, Kookmin University , Seoul 02707, Republic of Korea.


Therapeutic effects of photodynamic therapy (PDT) are limited by cancer hypoxia because the PDT process is dependent on O2 concentration. Herein, we design biocompatible manganese ferrite nanoparticle-anchored mesoporous silica nanoparticles (MFMSNs) to overcome hypoxia, consequently enhancing the therapeutic efficiency of PDT. By exploiting the continuous O2-evolving property of MnFe2O4 nanoparticles through the Fenton reaction, MFMSNs relieve hypoxic condition using a small amount of nanoparticles and improve therapeutic outcomes of PDT for tumors in vivo. In addition, MFMSNs exhibit T2 contrast effect in magnetic resonance imaging (MRI), allowing in vivo tracking of MFMSNs. These findings demonstrate great potential of MFMSNs for theranostic agents in cancer therapy.

[Indexed for MEDLINE]

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