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Helicobacter. 2017 Oct;22(5). doi: 10.1111/hel.12401. Epub 2017 Jul 24.

Antibody reactivity against Helicobacter pylori proteins in a sample of the Spanish adult population in 2008-2013.

Author information

1
Environmental and Cancer Epidemiology Area, National Center of Epidemiology, Instituto de Salud Carlos III, Madrid, Spain.
2
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER of Epidemiology and Public Health), Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
3
Division of Molecular Diagnostics of Oncogenic Infections, Infection, Inflammation and Cancer Program, German Cancer Research Center (DKFZ), Heidelberg, Germany.
4
Department of Microbiology, Ramón y Cajal University Hospital (IRYCIS), Madrid, Spain.
5
ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
6
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
7
Universitat Pompeu Fabra (UPF), Barcelona, Spain.
8
Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain.
9
Cancer Prevention and Control Program, Catalan Institute of Oncology-IDIBELL, Hospitalet de Llobregat, Spain.
10
The Research Group in Gene, Environment and Health Interactions (GIGAS), University of León, León, Spain.
11
Faculty of Health Sciences, Area of Preventive Medicine and Public Health, Department of Biomedical Sciences, University of León, León, Spain.
12
Public Health Division of Gipuzkoa, BioDonostia Research Institute, San Sebastián, Spain.
13
Instituto de Salud Pública de Navarra - Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
14
IUOPA, University of Oviedo, Oviedo, Spain.
15
IDIVAL, University of Cantabria, Santander, Spain.
16
Gastroenterology Department, Sagunto University Hospital, Sagunto, Spain.
17
Gastroenterology Department, La Fe University and Politecnic Hospital, Valencia, Spain.
18
Centro de Investigación en Recursos Naturales, Salud, y Medio Ambiente (RENSMA), Universidad de Huelva, Huelva, Spain.
19
Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain.
20
Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada Health Research Institute (ibs.GRANADA), Granada, Spain.
21
Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain.
22
Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Spain.
23
Spanish Network for Research in Infectious Diseases, (REIPI) Red Española de Investigación en Patología Infecciosa, Sevilla, Spain.

Abstract

BACKGROUND:

Differences in Helicobacter pylori protein expression have been related to the risk of severe gastric diseases. In Spain, a marked geographic pattern in gastric cancer mortality has long been reported.

OBJECTIVE:

To characterize antibody reactivity patterns against 16 H. pylori proteins, by age, sex, and region of birth, in a large sample of the Spanish adult population.

MATERIALS AND METHODS:

Antibody reactivity was quantified by H. pylori multiplex serology in a sample from the control group of the multicase-control study MCC-Spain. For this analysis, 2555 population-based controls were included. Each participant was classified as seropositive or seronegative for each protein according to specific cutoffs. Overall H. pylori seroprevalence was defined as positivity against ≥4 proteins. Descriptive analyses by age, sex, and region of birth were performed for both seroprevalence and seroreactivity (continuous measure). Differences among groups were tested by logistic and linear regression models.

RESULTS:

Overall H. pylori seroprevalence increased with age in both sexes. For ages 55-74, seroprevalence was lower in women than in men (84% vs 92%, P<.001). Region of birth explained 7% of the variability in seroprevalence. Among H. pylori seropositive subjects, proteins with the highest seroprevalence were GroEL, NapA, HP231, and Omp. Seropositivity for most of the proteins increased or remained stable with age, rising mainly for CagA, GroEL, and HyuA in women. A clear cohort effect was not observed.

CONCLUSIONS:

This is the first study to describe the antibody patterns against 16 H. pylori proteins in the Spanish population. We found variability in the H. pylori antibody profiles according to both individual factors such as age and sex, and environmental factors such as the region of birth. The slightness of the reduction in seropositivity with decreasing age highlights the ongoing importance of this infection.

KEYWORDS:

Helicobacter pylori ; multiplex serology; seroepidemiologic studies; seroprevalence; seroreactivity

PMID:
28737284
DOI:
10.1111/hel.12401
[Indexed for MEDLINE]

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