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Phys Med. 2017 Oct;42:292-297. doi: 10.1016/j.ejmp.2017.07.009. Epub 2017 Jul 21.

Optimization of GATE simulations for whole-body planar scintigraphic acquisitions using the XCAT male phantom with 177Lu-DOTATATE biokinetics in a Siemens Symbia T2.

Author information

1
Inserm, UMR1037 CRCT, F-31000 Toulouse, France; Université Toulouse III - Paul Sabatier, Toulouse, France; Instituto de Radioproteção e Dosimetria, Rio de Janeiro, Brazil. Electronic address: gustavo@ird.gov.br.
2
Instituto de Radioproteção e Dosimetria, Rio de Janeiro, Brazil.
3
Université de Lyon, CREATIS, CNRS UMR5220, Inserm U1044, 5 INSA-Lyon, Université Lyon 1, Centre Léon Bérard, France.
4
Inserm, UMR1037 CRCT, F-31000 Toulouse, France; Université Toulouse III - Paul Sabatier, Toulouse, France.

Abstract

Simulations of planar whole body acquisitions in therapeutic procedures are often extensively time-consuming and therefore rarely used. However, optimising tools and variance reduction techniques can be employed to overcome this problem. In this paper, a variety of features available in GATE are explored and their capabilities to reduce simulation time are evaluated. For this purpose, the male XCAT phantom was used as a virtual patient with 177Lu-DOTATATE pharmacokinetic for whole body planar acquisition simulations in a Siemens Symbia T2 model. Activity distribution was divided into 8 compartments that were simulated separately. GATE optimization techniques included reducing the amount of time spent in both voxel and detector tracking. Some acceleration techniques led to a decrease of CPU-time by a factor of 167, while image statistics were kept constant. In that context, the simulation of therapeutic procedure imaging would still require 46days on a single CPU, but this could be reduced to hours on a dedicated cluster.

KEYWORDS:

(177)Lu; GATE; Monte Carlo simulation; Nuclear medicine

PMID:
28736285
DOI:
10.1016/j.ejmp.2017.07.009
[Indexed for MEDLINE]

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