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J Insect Physiol. 2018 Apr;106(Pt 1):36-46. doi: 10.1016/j.jinsphys.2017.07.007. Epub 2017 Jul 19.

Serotonergic network in the subesophageal zone modulates the motor pattern for food intake in Drosophila.

Author information

1
Department of Molecular Brain Physiology, Limes Institute, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany. Electronic address: schoofs@uni-bonn.de.
2
Department of Molecular Brain Physiology, Limes Institute, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany.

Abstract

The functional organization of central motor circuits underlying feeding behaviors is not well understood. We have combined electrophysiological and genetic approaches to investigate the regulatory networks upstream of the motor program underlying food intake in the Drosophila larval central nervous system. We discovered that the serotonergic network of the CNS is able to set the motor rhythm frequency of pharyngeal pumping. Pharmacological experiments verified that modulation of the feeding motor pattern is based on the release of serotonin. Classical lesion and laser based cell ablation indicated that the serotonergic neurons in the subesophageal zone represent a redundant network for motor control of larval food intake.

KEYWORDS:

Cell ablation; Feeding behavior; Fluoxetine; Motor pattern; Pharyngeal pump; Serotonin (5-HT); Subesophageal zone (SEZ)

PMID:
28735009
DOI:
10.1016/j.jinsphys.2017.07.007
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