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Alzheimers Dement. 2018 Feb;14(2):130-139. doi: 10.1016/j.jalz.2017.06.2270. Epub 2017 Jul 21.

Dementia prevalence and incidence in a federation of European Electronic Health Record databases: The European Medical Informatics Framework resource.

Author information

1
Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
2
Department of Clinical Medicine, Aarhus University, Aarhus N, Denmark.
3
THIN Contacts, THIN, 1 Canal Side Studios, London, United Kingdom.
4
Real World Data and Health Analytics Department, GSK, Uxbridge, Middlesex, United Kingdom.
5
Janssen Pharmaceuticals Research & Development, Mill Valley, South San Francisco, CA, USA.
6
Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Biomedical Informatics, Harvard Medical School & Children's Hospital Informatics Program, Boston Children's Hospital, Boston, MA, USA.
7
Roche Products Ltd, Welwyn Garden City, United Kingdom.
8
Agenzia Regionale di Sanità della Toscana, Florence, Italy.
9
Clinical Development and Medical Affairs, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA.
10
Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Real World Evidence (Epidemiology), GSK R&D, Uxbridge, Middlesex, United Kingdom.
11
Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM), Universitat Pompeu Fabra, Barcelona, Catalonia, Spain.
12
Janssen Pharmaceutical Research and Development, Titusville NJ, USA.
13
Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.
14
Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands; Dipartimento di Scienze Biomediche, Odontoiatriche e Immagini Morfologiche e Funzionali, Università degli Studi di Messina, Messina, Italy.
15
Alzheimer Centre, School for Mental Health and Neuroscience (MHeNS), University Medical Centre Maastricht, Maastricht University, Maastricht, The Netherlands; Department of Neurology, Alzheimer Center, Neuroscience Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
16
Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; South London and Maudsley NHS Foundation Trust, London, United Kingdom. Electronic address: robert.stewart@kcl.ac.uk.

Abstract

INTRODUCTION:

The European Medical Information Framework consortium has assembled electronic health record (EHR) databases for dementia research. We calculated dementia prevalence and incidence in 25 million persons from 2004 to 2012.

METHODS:

Six EHR databases (three primary care and three secondary care) from five countries were interrogated. Dementia was ascertained by consensus harmonization of clinical/diagnostic codes. Annual period prevalences and incidences by age and gender were calculated and meta-analyzed.

RESULTS:

The six databases contained 138,625 dementia cases. Age-specific prevalences were around 30% of published estimates from community samples and incidences were around 50%. Pooled prevalences had increased from 2004 to 2012 in all age groups but pooled incidences only after age 75 years. Associations with age and gender were stable over time.

DISCUSSION:

The European Medical Information Framework initiative supports EHR data on unprecedented number of people with dementia. Age-specific prevalences and incidences mirror estimates from community samples in pattern at levels that are lower but increasing over time.

KEYWORDS:

Dementia; Electronic Health Records; European Medical Informatics Framework; Incidence; Prevalence

PMID:
28734783
DOI:
10.1016/j.jalz.2017.06.2270
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