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Biol Psychol. 2017 Sep;128:82-88. doi: 10.1016/j.biopsycho.2017.07.009. Epub 2017 Jul 20.

Atypical interference control in children with AD/HD with elevated theta/beta ratio.

Author information

1
School of Psychology, University of Wollongong, Wollongong, NSW, Australia; Brain & Behaviour Research Institute, University of Wollongong, Wollongong, NSW, Australia.
2
School of Psychology, University of Wollongong, Wollongong, NSW, Australia.
3
Peking University Sixth Hospital/Institute of Mental Health, Beijing, China; National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China.
4
State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, China.
5
School of Psychology, University of Wollongong, Wollongong, NSW, Australia; Brain & Behaviour Research Institute, University of Wollongong, Wollongong, NSW, Australia. Electronic address: sjohnsto@uow.edu.au.
6
Peking University Sixth Hospital/Institute of Mental Health, Beijing, China; National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China. Electronic address: sunlioh@bjmu.edu.cn.

Abstract

The theta/beta ratio (TBR) is a major area of interest within electroencephalogram (EEG) research in AD/HD. While researchers suggest a prognostic role for TBR in AD/HD, its relationship to behavior remains uncertain. Recent evidence suggests that elevated TBR in AD/HD may be related to atypical inhibition, particularly at an attentional level. This study aimed to examine the performance on three inhibitory tasks of children with AD/HD. Fifty-eight children with AD/HD participated, divided into an elevated TBR (ET) group and a control group (CT). A behavioral disassociation was found - compared to CT, ET showed more difficulty in inhibiting surrounding stimuli but had less day-to-day inhibitory issues measured by BRIEF. There was no significant group difference on response inhibition. The results support the prognostic value of TBR in AD/HD. Elevated TBR may be an inhibitory biomarker; further studies are needed to explore the behavioral implications in patients without elevated TBR.

KEYWORDS:

AD/HD; Biomarker; EEG; Inhibition; Interference control; Theta/beta ratio

PMID:
28734758
DOI:
10.1016/j.biopsycho.2017.07.009
[Indexed for MEDLINE]

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