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Trop Med Int Health. 2017 Oct;22(10):1322-1327. doi: 10.1111/tmi.12933. Epub 2017 Aug 11.

Association of Toxoplasma gondii infection with schizophrenia and its relationship with suicide attempts in these patients.

Author information

1
Department of Food Hygiene and Public Heath, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
2
Department of Psychiatry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Abstract

OBJECTIVES:

To investigate the association between schizophrenia and Toxoplasma gondii, and to assess the association of infection with suicide attempts and age of onset of schizophrenia in these patients.

METHODS:

Case-control study Fars Province, southern Iran. Cases were individuals with psychiatric diagnosis of schizophrenia as per Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria. Controls were healthy blood donors, frequency-matched with patients according to age and sex. For the detection of IgG antibodies, enzyme-linked immunosorbent assay (ELISA) was used. Data about demographic information in all subjects and duration of illness and history of suicide attempts in patients with schizophrenia were collected using a brief questionnaire and hospital records. Chi-square test and multivariable logistic regression were used for statistical analyses.

RESULTS:

Among 99 cases, 42 individuals (42%) were positive for T. gondii antibody, vs. 41 (27%) among 152 controls (OR = 2, 95% CI: 1.2-3.4, P = 0.012). We compared the suicide attempts in patients with schizophrenia based on their T. gondii serologic status. There was a lower rate of suicide attempts in seropositive male patients than seronegative ones (OR = 0.3, 95% CI: 0.1-0.97, P = 0.04). Age of onset of schizophrenia did not differ between T. gondii-infected and non-infected patients.

CONCLUSIONS:

These findings may have implications for schizophrenia and suicide prevention programmes. However, clearly further studies are required to confirm them.

KEYWORDS:

Toxoplasma gondii ; Iran; Irán; Schizophrenia; Suicide; esquizofrenia; schizophrénie; suicide; suicidio

PMID:
28734096
DOI:
10.1111/tmi.12933
[Indexed for MEDLINE]
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