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J Headache Pain. 2017 Dec;18(1):74. doi: 10.1186/s10194-017-0783-5. Epub 2017 Jul 21.

Assessment of gray and white matter structural alterations in migraineurs without aura.

Zhang J1, Wu YL2,3, Su J2, Yao Q2, Wang M1, Li GF2,3, Zhao R2,3, Shi YH2,3, Zhao Y2, Zhang Q2, Lu H1, Xu S1, Qin Z1, Cui GH2,3, Li J1, Liu JR4,5, Du X6.

Author information

1
Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, School of Physics and Materials Science, East China Normal University, 3663 North Zhong-Shan Road, 200062, Shanghai, People's Republic of China.
2
Department of Neurology and Jiuyuan Municipal Stroke Center, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, 200011, Shanghai, People's Republic of China.
3
Clinical Research Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
4
Department of Neurology and Jiuyuan Municipal Stroke Center, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, 200011, Shanghai, People's Republic of China. liujr021@vip.163.com.
5
Clinical Research Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China. liujr021@vip.163.com.
6
Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, School of Physics and Materials Science, East China Normal University, 3663 North Zhong-Shan Road, 200062, Shanghai, People's Republic of China. xxdu@phy.ecnu.edu.cn.

Abstract

BACKGROUND:

Migraine constitute a disorder characterized by recurrent headaches, and have a high prevalence, a high socio-economic burden and severe effects on quality of life. Our previous fMRI study demonstrated that some brain regions are functional alterations in migraineurs. As the function of the human brain is related to its structure, we further investigated white and gray matter structural alterations in migraineurs.

METHODS:

In current study, we used surface-based morphometry, voxel-based morphometry and diffusion tensor imaging analyses to detect structural alterations of the white matter and gray matter in 32 migraineurs without aura compared with 32 age- and gender-matched healthy controls.

RESULTS:

We found that migraineurs without aura exhibited significantly increased gray matter volume in the bilateral cerebellar culmen, increased cortical thickness in the lateral occipital-temporal cortex, decreased cortical thickness in the right insula, increased gyrification index in left postcentral gyrus, superior parietal lobule and right lateral occipital cortex, and decreased gyrification index in the left rostral middle frontal gyrus compared with controls. No significant change in white matter microstructure was found in DTI analyses.

CONCLUSION:

The significantly altered gray matter brain regions were known to be associated with sensory discrimination of pain, multi-sensory integration and nociceptive information processing and were consistent with our previous fMRI study, and may be involved in the pathological mechanism of migraine without aura.

KEYWORDS:

Diffusion tensor imaging; Magnetic resonance imaging; Migraine without aura; Surface-based morphometry; Voxel-based morphometry

PMID:
28733941
PMCID:
PMC5520823
DOI:
10.1186/s10194-017-0783-5
[Indexed for MEDLINE]
Free PMC Article

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