Engineered nanoparticles for the detection, treatment and prevention of atherosclerosis: how close are we?

Drug Discov Today. 2017 Sep;22(9):1438-1446. doi: 10.1016/j.drudis.2017.07.006. Epub 2017 Jul 18.

Abstract

Atherosclerosis is one of the leading causes of morbidity and mortality worldwide. Nanotechnology has provided the possibility of designing nanoparticles that can translocate through tissues and home in to atherosclerotic plaques to achieve desired diagnostic, therapeutic, theranostic or 'theralivery' outcomes. Although nanomedicine approaches have demonstrated exciting possibilities, clinical reality is still distant and challenges are aplenty, such as specificity of targeting and nanotoxicity. Nevertheless, developments in formulations, delivery strategies and experimental models over the coming years will generate new knowledge to define the true potential of this field. This review discusses the most recent developments, current challenges and future possibilities.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Atherosclerosis* / diagnosis
  • Atherosclerosis* / drug therapy
  • Atherosclerosis* / prevention & control
  • Disease Progression
  • Drug Carriers / administration & dosage
  • Drug Carriers / therapeutic use*
  • Humans
  • Nanoparticles / administration & dosage
  • Nanoparticles / therapeutic use*

Substances

  • Drug Carriers