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Carbohydr Polym. 2017 Oct 1;173:223-232. doi: 10.1016/j.carbpol.2017.06.006. Epub 2017 Jun 2.

Fabrication and characterization of hollow starch nanoparticles by gelation process for drug delivery application.

Author information

1
College of Food Science and Engineering, Qingdao Agricultural University, Qingdao, Shandong, 266109, China.
2
Central Laboratory, Qingdao Agricultural University, Qingdao, Shandong, 266109, China.
3
College of Food Science and Engineering, Qingdao Agricultural University, Qingdao, Shandong, 266109, China. Electronic address: phdsun@163.com.
4
College of Food Science and Engineering, Qingdao Agricultural University, Qingdao, Shandong, 266109, China. Electronic address: xiongliu821@163.com.

Abstract

Hollow nanoparticles (HNPs) have been widely regarded as controlled drug carriers owing to their advantages, such as high drug-loading efficiency and superior control over drug delivery and release. In this study, a facile and efficient strategy has been exploited for preparation of hollow starch nanoparticles (HSNPs) via a sacrificial hard-template process using gelled starch as the shell. These nanocapsules have been characterized through various techniques, including transmission electron microscopy, differential scanning calorimetry, X-ray diffraction, and Fourier transform infrared spectroscopy. The HSNPs have diameters ranging from 30nm to 300nm, with shell thickness of 5-10nm. X-ray diffraction analysis has revealed that HSNPs exhibit B+V type diffraction peaks with a relative crystallinity of 34.2%. Doxorubicin hydrochloride (DOX·HCl) was readily encased in the nanocarriers with a high loading efficiency (97.56%) and a high loading content (37.12%). In addition, no cytotoxicity for normal liver cells was found in HSNPs. However, DOX·HCl-loaded HSNPs exhibited clear cytotoxicity for liver hepatocellular cells. Thus, the hollow starch nanoparticles form a highly promising platform for cancer therapy.

KEYWORDS:

Calcium carbonate; Drug encapsulation; Gel; Hollow nanocarriers; Starch coating

PMID:
28732861
DOI:
10.1016/j.carbpol.2017.06.006
[Indexed for MEDLINE]

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