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BMC Res Notes. 2017 Jul 21;10(1):302. doi: 10.1186/s13104-017-2622-9.

Intraperitoneal lactate/pyruvate ratio and the level of glucose and glycerol concentration differ between patients surgically treated for upper and lower perforations of the gastrointestinal tract: a pilot study.

Author information

1
Department of Surgery, Odense University Hospital, 5000, Odense C, Denmark. jonasemilsabroe@gmail.com.
2
Department of Surgery, Odense University Hospital, 5000, Odense C, Denmark.
3
Department of Anaesthesiology and Intensive Care, Odense University Hospital, 5000, Odense C, Denmark.

Abstract

BACKGROUND:

Secondary peritonitis is a condition associated with high morbidity and mortality. Continuous postoperative monitoring of patients to ensure timely intervention to treat complications without delay is important for survival and outcome. We aimed to (1) investigate potential differences in postoperative intraperitoneal biomarker levels between patients with upper and lower gastrointestinal tract lesion, and (2) compare postoperative biomarker levels between complicated and uncomplicated patients.

METHODS:

We included a total of 15 consecutive patients operated for upper (n = 7) and lower (n = 8) gastrointestinal tract perforation. We registered postoperative complications during a 30 days follow up-period. Complications were defined as intraabdominal complications, septic shock, and mortality. 5 patients were complicated. A microdialysis catheter was placed intraperitoneally in each patient. Samples were collected every 4th hour for up to 7 postoperative days. Samples were analysed for concentrations of glucose, lactate, pyruvate and glycerol.

RESULTS:

Microdialysis results showed that patients with upper gastrointestinal tract lesions had significantly higher levels of postoperative intraperitoneal glucose and glycerol concentrations, as well as lower lactate/pyruvate ratios and lactate/glucose ratios. In the group with perforation of the lower gastrointestinal tract, those patients with a complicated course showed lower levels of postoperative intraperitoneal glucose concentration and glycerol concentration and higher lactate/pyruvate ratios and lactate/glucose ratios than those patients with an uncomplicated course.

CONCLUSION:

Patients with upper and lower gastrointestinal tract lesions showed differences in postoperative biomarker levels. A difference was also seen between patients with complicated and uncomplicated postoperative courses.

KEYWORDS:

Glycerol; Intraperitoneal microdialysis; Lactate/glucose ratio; Lactate/pyruvate ratio; Peritonitis

PMID:
28732549
PMCID:
PMC5521133
DOI:
10.1186/s13104-017-2622-9
[Indexed for MEDLINE]
Free PMC Article

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