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Laryngoscope. 2018 Jan;128(1):37-42. doi: 10.1002/lary.26778. Epub 2017 Jul 21.

Association between systemic antibiotic and corticosteroid use for chronic rhinosinusitis and quality of life.

Author information

1
Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts, U.S.A.
2
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, U.S.A.
3
Division of Otolaryngology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, U.S.A.
4
Department of Otolaryngology and Communications Enhancement, Boston Children's Hospital, Boston, Massachusetts, U.S.A.

Abstract

OBJECTIVE:

We sought to establish the significance of querying chronic rhinosinusitis (CRS) patients about their past CRS-related oral antibiotic and corticosteroid usage by determining the association between these metrics and patients' quality of life (QoL).

STUDY DESIGN:

Cross-sectional study.

METHODS:

A total of 157 patients with CRS were prospectively recruited. CRS-specific QoL was measured using the 22-item Sinonasal Outcome Test (SNOT-22). General health-related QoL was measured using the EuroQoL five-dimensional questionnaire visual analog scale. Associations were sought between these measures of QoL and frequency of CRS-related oral antibiotic and corticosteroid usage reported by the participants in the prior 3 and 12 months.

RESULTS:

More frequent antibiotic and corticosteroid use was significantly associated with worse CRS-specific and general health-related QoL, whether querying medication use over the prior 3 months or over the prior 12 months (P < 0.001 in all cases). The effect size of CRS-related antibiotic use during the prior 3 months on CRS-specific QoL (SNOT-22 score) was significantly greater than for use during the prior 12 months. However, there was no other statistically significant difference in effect size for association between QoL and CRS-related antibiotic or corticosteroid use in the prior 3 months versus prior 12 months. These results were independent of the presence or absence of polyps.

CONCLUSION:

More frequent past CRS-related oral antibiotic and corticosteroid use, regardless of time period queried (3 months or 12 months) is associated with significant decrease in CRS-specific and general health-related QoL. CRS-related systemic medication use is an important indicator of CRS patients' QOL that easily can be queried and utilized in both clinical and research settings.

LEVEL OF EVIDENCE:

2c. Laryngoscope, 128:37-42, 2018.

KEYWORDS:

Chronic rhinosinusitis; QoL; SNOT-22; systemic antibiotics; systemic corticosteroids

PMID:
28731529
DOI:
10.1002/lary.26778
[Indexed for MEDLINE]

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