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Hum Brain Mapp. 2017 Oct;38(10):5292-5306. doi: 10.1002/hbm.23738. Epub 2017 Jul 21.

Analysis of structure-function network decoupling in the brain systems of spastic diplegic cerebral palsy.

Lee D1,2, Pae C2,3, Lee JD4, Park ES5, Cho SR5, Um MH2, Lee SK6, Oh MK3, Park HJ2,3,6,7,8.

Author information

1
Faculty of Psychology and Education Sciences, University of Coimbra, Coimbra, Portugal.
2
BK21 PLUS Project for Medical Science, Korea.
3
Department of Nuclear Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
4
Department of Radiology and Nuclear Medicine, International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, South Korea.
5
Department of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
6
Department of Radiology, Yonsei University College of Medicine, Seoul, Republic of Korea.
7
Department of Cognitive Science, Yonsei University, Seoul, Republic of Korea.
8
Center for Systems and Translational Brain Sciences, Institute of Human Complexity and Systems Science, Yonsei University, Seoul, Republic of Korea.

Abstract

Manifestation of the functionalities from the structural brain network is becoming increasingly important to understand a brain disease. With the aim of investigating the differential structure-function couplings according to network systems, we investigated the structural and functional brain networks of patients with spastic diplegic cerebral palsy with periventricular leukomalacia compared to healthy controls. The structural and functional networks of the whole brain and motor system, constructed using deterministic and probabilistic tractography of diffusion tensor magnetic resonance images and Pearson and partial correlation analyses of resting-state functional magnetic resonance images, showed differential embedding of functional networks in the structural networks in patients. In the whole-brain network of patients, significantly reduced global network efficiency compared to healthy controls were found in the structural networks but not in the functional networks, resulting in reduced structural-functional coupling. On the contrary, the motor network of patients had a significantly lower functional network efficiency over the intact structural network and a lower structure-function coupling than the control group. This reduced coupling but reverse directionality in the whole-brain and motor networks of patients was prominent particularly between the probabilistic structural and partial correlation-based functional networks. Intact (or less deficient) functional network over impaired structural networks of the whole brain and highly impaired functional network topology over the intact structural motor network might subserve relatively preserved cognitions and impaired motor functions in cerebral palsy. This study suggests that the structure-function relationship, evaluated specifically using sparse functional connectivity, may reveal important clues to functional reorganization in cerebral palsy. Hum Brain Mapp 38:5292-5306, 2017.

KEYWORDS:

brain network; cerebral palsy; functional reorganization; structure-function relationship

PMID:
28731515
DOI:
10.1002/hbm.23738
[Indexed for MEDLINE]

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