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Nat Rev Drug Discov. 2017 Oct;16(10):718-735. doi: 10.1038/nrd.2017.116. Epub 2017 Jul 21.

Senescent cells: an emerging target for diseases of ageing.

Author information

1
Departments of Biochemistry and Molecular Biology, Mayo Clinic.
2
Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 1st St. SW, Rochester, Minnesota 55905, USA.
3
Unity Biotechnology, 3280 Bayshore Boulevard Suite 100, Brisbane, California 94005, USA.

Abstract

Chronological age represents the single greatest risk factor for human disease. One plausible explanation for this correlation is that mechanisms that drive ageing might also promote age-related diseases. Cellular senescence, which is a permanent state of cell cycle arrest induced by cellular stress, has recently emerged as a fundamental ageing mechanism that also contributes to diseases of late life, including cancer, atherosclerosis and osteoarthritis. Therapeutic strategies that safely interfere with the detrimental effects of cellular senescence, such as the selective elimination of senescent cells (SNCs) or the disruption of the SNC secretome, are gaining significant attention, with several programmes now nearing human clinical studies.

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PMID:
28729727
PMCID:
PMC5942225
DOI:
10.1038/nrd.2017.116
[Indexed for MEDLINE]
Free PMC Article

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