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J Sci Med Sport. 2018 Mar;21(3):286-290. doi: 10.1016/j.jsams.2017.06.018. Epub 2017 Jul 4.

Effect of a physical activity intervention on suPAR levels: A randomized controlled trial.

Author information

1
Mental Health Centre Glostrup, Copenhagen University Hospital, Denmark. Electronic address: stofferrohde1@gmail.com.
2
Department of Clinical Medicine, Aalborg University, Denmark; Department of Psychiatry, Aalborg University Hospital, Denmark; Department of Clinical Epidemiology, Aalborg University Hospital, Denmark.
3
Faculty of Humanities, Sports and Educational Science, Department of Sports, Physical Education and Outdoor Studies, University College of Southeast Norway, Norway.
4
Department of Clinical Medicine, Aalborg University, Denmark.
5
Mental Health Centre Glostrup, Copenhagen University Hospital, Denmark; Department of Clinical Medicine, Aalborg University, Denmark; Department of Psychiatry, Aalborg University Hospital, Denmark.

Abstract

OBJECTIVES:

Soluble urokinase-type plasminogen activator receptor (suPAR) is a novel inflammatory marker, associated with lifestyle diseases and mortality risk. No studies have investigated whether physical activity may reduce suPAR levels using a randomized controlled design.

DESIGN AND METHODS:

suPAR and C-reactive protein (CRP) levels were determined in blood samples from a previous randomized controlled trial with Pakistani immigrants in Norway, 2008. The study included physically inactive men that were randomized to an intervention group (supervised group exercises) or a control group and followed for 5 months. A linear regression model was used and adjusted for age, inactivity level at baseline, and mean difference in CRP levels.

RESULTS:

Overall, 80 and 53 participants were included in the intervention and control group, respectively. Obesity and smoking were associated with higher suPAR levels at baseline. The intervention group had a mean suPAR level of 2.65 (95% CI=2.48-2.78)ng/mL at baseline compared to 2.80 (95% CI=2.65-2.95)ng/mL at post-test, and thereby significantly increased suPAR levels after intervention (p=0.02). In the control group, mean suPAR level significantly increased from 2.93 (95% CI=2.68-3.16)ng/mL at baseline to 3.09 (95% CI=2.81-3.38)ng/mL at post-test (p=0.04). When comparing change from baseline to post-test in suPAR levels for the intervention group versus the control group, no significant change in the unadjusted model was found (β=-0.002, 95% CI=-0.219-0.215). Similar results were found for CRP levels.

CONCLUSION:

There was no change in suPAR levels after regular exercise compared to a control group implying that suPAR rather reflects underlying harmful inflammatory responses associated with disease development.

KEYWORDS:

C-reactive protein; Exercise; Immunology; Inflammatory; Soluble urokinase-type plasminogen activator receptor

PMID:
28728886
DOI:
10.1016/j.jsams.2017.06.018
[Indexed for MEDLINE]

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