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Cardiovasc Diabetol. 2017 Jul 20;16(1):92. doi: 10.1186/s12933-017-0568-9.

Circulating sortilin level as a potential biomarker for coronary atherosclerosis and diabetes mellitus.

Oh TJ1,2, Ahn CH1, Kim BR1,2, Kim KM1,2, Moon JH1,2, Lim S1,2, Park KS1, Lim C3,4, Jang H1,2, Choi SH5,6.

Author information

1
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
2
Department of Internal Medicine, Seoul National University Bundang Hospital, 300, Gumi-dong, Bundang-gu, Seongnam, 463-070, South Korea.
3
Department of Thoracic and Cardiovascular Surgery, Seoul National University College of Medicine, Seoul, South Korea.
4
Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea.
5
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea. drshchoi@snu.ac.kr.
6
Department of Internal Medicine, Seoul National University Bundang Hospital, 300, Gumi-dong, Bundang-gu, Seongnam, 463-070, South Korea. drshchoi@snu.ac.kr.

Abstract

CONTEXT:

A previous genome-wide association study showed that a genetic variant of sortilin was associated with the risk of coronary artery disease (CAD). However, the role of circulating sortilin is still unknown. We investigated the potential role of plasma sortilin as a biomarker for CAD and diabetes mellitus.

METHODS:

We enrolled statin-naïve subjects with CAD (n = 31) who underwent coronary artery bypass surgery and control subjects (n = 116) who were free from CAD as evaluated by coronary CT angiography. The presence of diabetes mellitus was evaluated and plasma sortilin levels were measured with a commercial ELISA kit.

RESULTS:

Plasma sortilin levels were higher in subjects with CAD and subjects with diabetes mellitus than in those without CAD or diabetes mellitus. Subjects in the highest sortilin tertile group were older and had higher glucose and HbA1c levels, but lipid profiles in the three tertile groups were comparable. Multivariable logistic regression analysis revealed that sortilin levels were independently associated with CAD. In addition, the receiver operating characteristic curve analysis showed that plasma sortilin levels could identify the presence of CAD or diabetes mellitus.

CONCLUSIONS:

Elevated circulating sortilin levels are associated with CAD and diabetes mellitus and can be used as a biomarker of both diseases in statin-naïve subjects.

KEYWORDS:

Biomarker; Coronary artery disease; Diabetes mellitus; Proneurotensin; Sortilin

PMID:
28728579
PMCID:
PMC5520342
DOI:
10.1186/s12933-017-0568-9
[Indexed for MEDLINE]
Free PMC Article

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