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Colloids Surf B Biointerfaces. 2017 Oct 1;158:431-440. doi: 10.1016/j.colsurfb.2017.07.028. Epub 2017 Jul 11.

Preparation of a 6-OH quaternized chitosan derivative through click reaction and its application to novel thermally induced/polyelectrolyte complex hydrogels.

Author information

1
School of Material Science and Engineering, Beijing Institute of Technology, Beijing 100081, PR China. Electronic address: cylsy@163.com.
2
School of Material Science and Engineering, Beijing Institute of Technology, Beijing 100081, PR China.
3
Department of Clinical Laboratory, Pudong New Area People's Hospital, Shanghai 201200, PR China.
4
Guangdong Fuyang Biotechnology Co.,Ltd, Heyuan, Guangdong 517000, PR China.

Abstract

In the present study, a chitosan derivative with long chain quaternary ammonium locating grafted at 6-OH (CTS-6-QAS) was designed and prepared via a novel click reaction. The structure and thermal stability of the products of each step were determined with Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA). Rheological tests indicate that CTS-6-QAS possesses excellent thermally induced hydrogel formation property in the presence of β-glycerophosphate (β-GP). Based on these results, a novel thermally induced/polyelectrolyte complex CTS-6-QAS/alginate (SA)/β-GP dual-network hydrogel was designed. This controllable preparation method can avoid the disadvantages of the preparation methods for single thermo-induced hydrogels and polyelectrolyte complex hydrogels, and promote the homogeneity of the hydrogel. Porous sponges were prepared by freeze-drying the CTS-6-QASSA/β-GP hydrogels. The effects of hydrogel preparation conditions on the porous structure and swelling property of the sponges were quantitatively investigated. Tea tree oil (TTO), a natural antibacterial agent, was successfully embedded in the hydrogel due to the lipophilicity of the long chain quaternary ammonium grafted at 6-OH of chitosan. The sustained release of TTO from the hydrogel was studied.

KEYWORDS:

Click reaction; Dual-network hydrogel; Locating graft; Polyelectrolyte complex; Tea tree oil; Thermally induced

PMID:
28728085
DOI:
10.1016/j.colsurfb.2017.07.028
[Indexed for MEDLINE]

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