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Colloids Surf B Biointerfaces. 2017 Oct 1;158:431-440. doi: 10.1016/j.colsurfb.2017.07.028. Epub 2017 Jul 11.

Preparation of a 6-OH quaternized chitosan derivative through click reaction and its application to novel thermally induced/polyelectrolyte complex hydrogels.

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School of Material Science and Engineering, Beijing Institute of Technology, Beijing 100081, PR China. Electronic address:
School of Material Science and Engineering, Beijing Institute of Technology, Beijing 100081, PR China.
Department of Clinical Laboratory, Pudong New Area People's Hospital, Shanghai 201200, PR China.
Guangdong Fuyang Biotechnology Co.,Ltd, Heyuan, Guangdong 517000, PR China.


In the present study, a chitosan derivative with long chain quaternary ammonium locating grafted at 6-OH (CTS-6-QAS) was designed and prepared via a novel click reaction. The structure and thermal stability of the products of each step were determined with Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA). Rheological tests indicate that CTS-6-QAS possesses excellent thermally induced hydrogel formation property in the presence of β-glycerophosphate (β-GP). Based on these results, a novel thermally induced/polyelectrolyte complex CTS-6-QAS/alginate (SA)/β-GP dual-network hydrogel was designed. This controllable preparation method can avoid the disadvantages of the preparation methods for single thermo-induced hydrogels and polyelectrolyte complex hydrogels, and promote the homogeneity of the hydrogel. Porous sponges were prepared by freeze-drying the CTS-6-QASSA/β-GP hydrogels. The effects of hydrogel preparation conditions on the porous structure and swelling property of the sponges were quantitatively investigated. Tea tree oil (TTO), a natural antibacterial agent, was successfully embedded in the hydrogel due to the lipophilicity of the long chain quaternary ammonium grafted at 6-OH of chitosan. The sustained release of TTO from the hydrogel was studied.


Click reaction; Dual-network hydrogel; Locating graft; Polyelectrolyte complex; Tea tree oil; Thermally induced

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