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Gut Microbes. 2017 Nov 2;8(6):616-620. doi: 10.1080/19490976.2017.1353842. Epub 2017 Aug 3.

New perspectives regarding the antiviral effect of vitamin A on norovirus using modulation of gut microbiota.

Author information

1
a College of Pharmacy , Sahmyook University , Seoul , Korea.
2
b Center for Human and Environmental Microbiome , Institute of Health and Environment, School of Public Health, Seoul National University , Seoul , Korea.

Abstract

Gut microbiota has been revealed to play an important role in various health conditions, and recent studies have suggested the modulation of gut microbiota as a therapeutic strategy. There is no effective treatment of norovirus infection, though vitamin A has been suggested to have an antiviral effect in an epidemiological study. We demonstrated that vitamin A significantly inhibited murine norovirus replication. Vitamin A supplementation significantly increased the abundance of Lactobacillus sp. during norovirus infection, which played a crucial role in antiviral efficacy, inhibiting murine norovirus. Therefore, we elaborated the antiviral effect of vitamin A via modulation of gut microbiota. Furthermore, we suggest a novel strategy, using potential probiotics, as having a protective and therapeutic effect on noroviral infection.

KEYWORDS:

IFN-β; Lactobacillus; gut microbiome; norovirus; vitamin A

PMID:
28727498
PMCID:
PMC5730389
DOI:
10.1080/19490976.2017.1353842
[Indexed for MEDLINE]
Free PMC Article

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