Format

Send to

Choose Destination
Benef Microbes. 2017 Aug 24;8(4):563-567. doi: 10.3920/BM2016.0185. Epub 2017 Jul 20.

Human milk oligosaccharide categories define the microbiota composition in human colostrum.

Author information

1
1 Functional Foods Forum, Faculty of Medicine, University of Turku, Itäinenpitkäkatu 4 A 5 krs., 20014 Turku, Finland.
2
2 Food Chemistry and Food Development, Department of Biochemistry, University of Turku, Vatselankatu 2, 20014 Turku, Finland.
3
3 Department of Pediatrics, University of Turku and Turku University Hospital, Kiinamyllynkatu 4-8, 20500 Turku, Finland.
4
4 Department of Pediatrics, University of California, 9500 Gilman Drive, La Jolla, CA 92093, USA.

Abstract

Human milk oligosaccharides (HMOs) are structurally diverse unconjugated glycans with a composition unique to each lactating mother. While HMOs have been shown to have an impact on the development of infant gut microbiota, it is not well known if HMOs also already affect milk microbial composition. To address this question, we analysed eleven colostrum samples for HMO content by high-pressure liquid chromatography and microbiota composition by quantitative PCR. Higher total HMO concentration was associated with higher counts of Bifidobacterium spp. (ρ=0.63, P=0.036). A distinctive effect was seen when comparing different HMO groups: positive correlations were observed between sialylated HMOs and Bifidobacterium breve (ρ=0.84, P=0.001), and non-fucosylated/non-sialylated HMOs and Bifidobacterium longum group (ρ=0.65, P=0.030). In addition to associations between HMOs and bifidobacteria, positive correlations were observed between fucosylated HMOs and Akkermansia muciniphila (ρ=0.70, P=0.017), and between fucosylated/sialylated HMOs and Staphylococcus aureus (ρ=0.75, P=0.007). Our results suggest that the characterised HMOs have an effect on specific microbial groups in human milk. Both oligosaccharides and microbes provide a concise inoculum for the compositional development of the infant gut microbiota.

KEYWORDS:

bifidobacteria; human milk oligosaccharide; microbiota

PMID:
28726512
DOI:
10.3920/BM2016.0185
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center