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Immunity. 2017 Jul 18;47(1):32-50. doi: 10.1016/j.immuni.2017.07.004.

Immunology of Food Allergy.

Author information

1
Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10034, USA.
2
Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10034, USA. Electronic address: hugh.sampson@mssm.edu.

Abstract

Many consider food allergy as the "second wave" of the allergy epidemic following the "first wave" of respiratory allergy, i.e., asthma and allergic rhinitis, plaguing westernized countries, with up to 8% of young children and 2%-3% of adults in the United States now affected by hypersensitivity reactions to various foods. In the past decade, there have been great strides in our understanding of the underlying immunopathogenesis of these disorders, which have led to improved diagnostic techniques, management strategies, and therapeutic approaches. Here we will review the most recent understanding of basic mechanisms underlying IgE-mediated food allergies and novel therapeutic approaches under investigation for both the prevention and treatment of IgE-mediated food allergies.

PMID:
28723552
DOI:
10.1016/j.immuni.2017.07.004
[Indexed for MEDLINE]
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