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Nat Immunol. 2017 Jul 19;18(8):826-831. doi: 10.1038/ni.3790.

A guiding map for inflammation.

Author information

1
Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.
2
Human Genomics Laboratory, Craiova University of Medicine and Pharmacy, Craiova, Romania.
3
Barts Cancer Institute, Queen Mary University of London, London, UK.
4
Division of Renal Diseases and Hypertension, University of Colorado, Denver, Aurora, Colorado, USA.
5
Digestive Health Research Institute, Case Western Reserve University, Cleveland, Ohio, USA.
6
Clinic of Endocrinology, Diabetes and Metabolism, University Hospital, University of Basel, Basel, Switzerland.
7
4th Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
8
Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
9
Department of Neurodegenerative Disease and Gerontopsychiatry/Neurology, University of Bonn, Bonn, Germany.
10
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
11
Division of Pediatric Allergy, Immunology, and Rheumatology, University of California at San Diego and Rady Children's Hospital of San Diego, San Diego, California, USA.
12
Department of Anesthesiology, Medicine, and Surgery, Washington University School of Medicine, St Louis, Missouri, USA.
13
Department of Medical Genetics, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
14
Inflammatory Disease Section, Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA.
15
TU Braunschweig, Zoological Institute and HZI, AG NIND, Braunschweig, Germany.
16
Institute of Innate Immunity, University Hospital Bonn, University of Bonn, Bonn, Germany.
17
Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
18
Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
19
Humanitas Clinica Research Center, Humanitas University, Milano, Italy.
20
School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
21
Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
22
Center of Experimental and Molecular Medicine, Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
23
Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
24
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School Boston, Massachusetts, USA.
25
Department of Dermatology, Radboud University Medical Center, Nijmegen, the Netherlands.
26
Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, Denver, Aurora, Colorado, USA.
27
Department of Medicine (Gastroenterology, Infectious Diseases, Rheumatology), Charité-Universitätsmedizin Berlin, Berlin, Germany.
28
Departments of Medicine and of Genetics, Cell Biology and Development, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
29
Department of Internal Medicine I, Gastroenterology, Hepatology &Endocrinology, Medical University Innsbruck, Innsbruck, Austria.
30
Department of Medicine, University of Colorado Denver, Aurora, Colorado, USA.

Abstract

Biologists, physicians and immunologists have contributed to the understanding of the cellular participants and biological pathways involved in inflammation. Here, we provide a general guide to the cellular and humoral contributors to inflammation as well as to the pathways that characterize inflammation in specific organs and tissues.

PMID:
28722720
PMCID:
PMC5939996
DOI:
10.1038/ni.3790
[Indexed for MEDLINE]
Free PMC Article

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