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Nat Immunol. 2017 Jul 19;18(8):851-860. doi: 10.1038/ni.3780.

Regulation of inflammation by microbiota interactions with the host.

Author information

1
Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, New York, USA.
2
Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, New York, USA.
3
Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, Cornell University, New York, New York, USA.

Abstract

The study of the intestinal microbiota has begun to shift from cataloging individual members of the commensal community to understanding their contributions to the physiology of the host organism in health and disease. Here, we review the effects of the microbiome on innate and adaptive immunological players from epithelial cells and antigen-presenting cells to innate lymphoid cells and regulatory T cells. We discuss recent studies that have identified diverse microbiota-derived bioactive molecules and their effects on inflammation within the intestine and distally at sites as anatomically remote as the brain. Finally, we highlight new insights into how the microbiome influences the host response to infection, vaccination and cancer, as well as susceptibility to autoimmune and neurodegenerative disorders.

PMID:
28722709
PMCID:
PMC5800875
DOI:
10.1038/ni.3780
[Indexed for MEDLINE]
Free PMC Article

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