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Metab Brain Dis. 2017 Dec;32(6):1843-1851. doi: 10.1007/s11011-017-0066-5. Epub 2017 Jul 18.

Anatomical specificity of the brain in the modulation of Neuroglobin and Cytoglobin genes after chronic bisphenol a exposure.

Author information

1
Laboratory of Molecular and Translational Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp/EPM), São Paulo, SP, Brazil.
2
Department of Pharmacy, State University of Centro-Oeste, Curitiba, Parana, Brazil.
3
Laboratory of Molecular and Translational Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp/EPM), São Paulo, SP, Brazil. ggiannocco@gmail.com.
4
Department of Biological Sciences, Universidade Federal de São Paulo, Diadema, SP, Brazil. ggiannocco@gmail.com.
5
Laboratório de Endocriologia Molecular e Translacional, Departamento de Medicina, Universidade Federal de São Paulo (UNIFESP), Rua Pedro de Toledo, Vila Clementino, Sao Paulo, SP, 04039032, Brazil. ggiannocco@gmail.com.

Abstract

The aim of this study was to investigate the influence of Bisphenol A (BPA) exposure on Neuroglobin (Ngb) and Cytoglobin (Cygb) as well as oxidative stress gene expression in the cerebellum, hippocampus, hypothalamus and cortex. Male Wistar rats were randomly divided into 3 groups: Control and two groups receiving 2 different daily BPA dosages, 5 or 25 mg/kg from postnatal day 50 (PND50) through PND90 and they were euthanized at PND105. In the cortex, we found an increase in Ngb gene expression and also in superoxide dismutase 1 and Catalase (Cat). In the cerebellum, we found an increase in Ngb and Cat, in the hypothalamus, there was a decrease in Cygb and an increase in glutathione peroxidase and Cat and in hypoxia-inducible factor 1 alpha (Hif1α) at the low dosage and a decrease in Hif1α at the high BPA dosage. Finally, in the hippocampus, we observed a decrease in Ngb and Cygb and an increase in Hif1α. In summary, BPA promotes the modulation of both Ngb and Cygb, but such changes occur by different mechanisms depending on the exposure dose and anatomical area.

KEYWORDS:

Bisphenol a; Brain; Cytoglobin; Neuroglobin; Reactive oxygen species

PMID:
28721559
DOI:
10.1007/s11011-017-0066-5
[Indexed for MEDLINE]

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