Format

Send to

Choose Destination
Clin Interv Aging. 2017 Jun 29;12:1041-1048. doi: 10.2147/CIA.S132884. eCollection 2017.

11C-PIB PET imaging reveals that amyloid deposition in cases with early-onset Alzheimer's disease in the absence of known mutations retains higher levels of PIB in the basal ganglia.

Author information

1
Department of Neurology, Chung-Ang University College of Medicine, Seoul.
2
Department of Neurology, Kangwon National University Hospital.
3
Department of Laboratory Medicine.
4
Department of Nuclear Medicine.
5
Department of Radiology, Chung-Ang University College of Medicine.
6
College of Bionano Technology, Gachon Bionano Research Institute, Gachon University.
7
Department of Nuclear Medicine, Kangwon National University Hospital.
8
Department of Neurology, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Gyeonggi-do, Republic of Korea.

Abstract

PURPOSE:

Early-onset Alzheimer's disease (EOAD) has a different pathologic burden and clinical features compared with late-onset Alzheimer's disease (LOAD). We examined the effects of age at onset on the burden and distribution of β-amyloid in patients with EOAD, in whom well-characterized mutations associated with Alzheimer's disease were absent.

METHODS:

We genotyped ApoE, APP, PSEN1 and PSEN2 in the patients with Alzheimer's disease: 9 patients with EOAD (age <65), 11 with LOAD (age >70) and 8 normal controls (NCs), all of whom had undergone 11C-labeled Pittsburgh compound B-positron emission tomography imaging.

RESULTS:

Patients with EOAD exhibited higher z scores and larger cluster sizes, and retained higher levels of Pittsburgh compound B in the bilateral thalamus and in some parts of the globus pallidus (P<0.05, false discovery rate).

CONCLUSION:

Distribution of amyloid deposition in EOAD outside the context of genetic mutations topographically showed some differences from that in LOAD.

KEYWORDS:

Alzheimer’s disease; Pittsburgh compound B; amyloid; amyloid PET; basal ganglia; early-onset Alzheimer’s disease

PMID:
28721032
PMCID:
PMC5500536
DOI:
10.2147/CIA.S132884
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Dove Medical Press Icon for PubMed Central
Loading ...
Support Center