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Nutr Cancer. 2017 Aug-Sep;69(6):862-872. doi: 10.1080/01635581.2017.1339097. Epub 2017 Jul 18.

Partial Substitution of Glucose with Xylitol Suppressed the Glycolysis and Selectively Inhibited the Proliferation of Oral Cancer Cells.

Author information

1
a Institute of Nutrition, Mahidol University , Nakhon Pathom , Thailand.
2
b Siriraj Center of Excellence for Stem Cell Research, Siriraj Hospital, Mahidol University , Bangkok , Thailand.
3
c Wang Pong Hospital , Wang Pong, Petchaburi , Thailand.
4
d Phu Khieo Hospital , Phak Pang, Phu Khieo, Chaiyaphum , Thailand.
5
e Chakkarat Hospital , Chakkarat, Nakhon Ratchasima , Thailand.
6
f Banbung Hospital , Bangbung, Chonburi , Thailand.
7
g Bhumibol Adulyadej Hospital , Saimai, Bangkok , Thailand.
8
h Vichaivej, Nongkhaem Hospital , Nongkhaem, Bangkok , Thailand.
9
i Krabi Hospital , Krabi , Thailand.
10
j Kangsanamnang Hospital , Nakornratchasima , Thailand.
11
k Huai krachao Hospital , Kanchanaburi , Thailand.

Abstract

Suitable diet for cancer survivors remains an unresolved challenge. Increased glucose utilization is a hallmark of various cancers. Therefore, alternative carbohydrate supplying normal tissue but retarding cancer growth is needed. This study investigated the effect of sugar alcohols on the proliferation of oral cancer cells compared to nontransformed cells and explored the mechanism. Six oral squamous cell carcinoma (CAL-27, FaDu, SCC4, SCC9, SCC15, and SCC25) and one nontransformed oral keratinocyte (OKF6/TERT2) lines were cultured in media containing 1 mg/ml glucose and 5.8 mg/ml xylitol or sorbitol, yielding equal energy input to control group (4.5 mg/ml glucose). Partial substitution of glucose with sugar alcohols especially xylitol significantly suppressed proliferation of oral cancer but not nontransformed cells. Despite the addition of isocaloric quantities of the sugars, cancer cells exposed to low glucose plus xylitol had retarded ATP generation and decreased activity of phosphofructokinase (PFK), the rate-limiting enzyme in glycolysis. Furthermore, D-xylulose, its key metabolic intermediate, enhanced the anticancer effect of xylitol. These findings suggested a selective anticancer activity of xylitol and the potential mechanism involving inhibition of glucose utilization. Partial substitution of glucose with xylitol may be a proper nutrient for oral cancer survivors, deserving further investigation in animal and clinical settings.

PMID:
28718681
DOI:
10.1080/01635581.2017.1339097
[Indexed for MEDLINE]

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