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J Dermatolog Treat. 2018 Mar;29(2):190-195. doi: 10.1080/09546634.2017.1357797. Epub 2017 Aug 1.

Selenium, zinc, copper, Cu/Zn ratio and total antioxidant status in the serum of vitiligo patients treated by narrow-band ultraviolet-B phototherapy.

Author information

1
a Laboratory of Cosmetology , Medical University of Bialystok , Bialystok , Poland.
2
b Department of Bromatology , Medical University of Bialystok , Bialystok , Poland.
3
c Department of Esthetic Medicine , Medical University of Bialystok , Bialystok , Poland.
4
d Outdoor-Patients Dermatological Department , Medical University of Bialystok, Clinical Hospital , Bialystok , Poland.

Abstract

BACKGROUND:

Vitiligo is a chronic, depigmenting skin disorder, whose pathogenesis is still unknown. Narrow band ultraviolet-B (NB-UVB) is now one of the most widely used treatment of vitiligo. It was suggested that trace elements may play a role in pathogenesis of vitiligo.

AIM:

The aim of this study was to estimate the concentration of selenium (Se), zinc (Zn), copper (Cu) and Cu/Zn ratio as well as total antioxidant status (TAS) in the serum of patients with vitiligo.

METHODS:

We assessed 50 patients with vitiligo and 58 healthy controls. Serum levels of Se, Zn and Cu were determined by the atomic absorption spectrometry method, and the Cu/Zn ratio was also calculated. TAS in serum was measured spectrophotometrically.

RESULT:

Serum concentration of Se in patients with vitiligo before and after phototherapy was significantly lower as compared to the control group. Zn level in the serum of patients decreased significantly after phototherapy. We observed higher Cu/Zn ratio (p < .05) in examined patients than in the control group and after NB-UVB. We have found decrease in TAS in the serum of vitiligo patients after NB-UVB.

CONCLUSIONS:

The current study showed some disturbances in the serum levels of trace elements and total antioxidant status in vitiligo patients.

KEYWORDS:

Vitiligo; copper; narrow band ultraviolet-B phototherapy; selenium; total antioxidant status; zinc

PMID:
28718676
DOI:
10.1080/09546634.2017.1357797
[Indexed for MEDLINE]

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