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Arch Toxicol. 2017 Sep;91(9):3039-3049. doi: 10.1007/s00204-017-2024-8. Epub 2017 Jul 17.

A review of drug-induced liver injury databases.

Author information

1
School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, People's Republic of China.
2
Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, SAR, People's Republic of China. aipinglu@hkbu.edu.hk.
3
School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, People's Republic of China. XZH0077@126.com.
4
Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, SAR, People's Republic of China. XZH0077@126.com.

Abstract

Drug-induced liver injuries have been a major focus of current research in drug development, and are also one of the major reasons for the failure and withdrawal of drugs in development. Drug-induced liver injuries have been systematically recorded in many public databases, which have become valuable resources in this field. In this study, we provide an overview of these databases, including the liver injury-specific databases LiverTox, LTKB, Open TG-GATEs, LTMap and Hepatox, and the general databases, T3DB, DrugBank, DITOP, DART, CTD and HSDB. The features and limitations of these databases are summarized and discussed in detail. Apart from their powerful functions, we believe that these databases can be improved in several ways: by providing the data about the molecular targets involved in liver toxicity, by incorporating information regarding liver injuries caused by drug interactions, and by regularly updating the data.

KEYWORDS:

Databases; Drug-induced liver injury; Hepatotoxicity; Liver toxicity; Review

PMID:
28717830
DOI:
10.1007/s00204-017-2024-8
[Indexed for MEDLINE]

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