Format

Send to

Choose Destination
Sci Rep. 2017 Jul 17;7(1):5547. doi: 10.1038/s41598-017-05507-6.

Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data.

Author information

1
Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom. s1517658@sms.ed.ac.uk.
2
Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom.
3
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom.
4
Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom.
5
Institute of Health and Wellbeing, Mental Health and Wellbeing Research Group, University of Glasgow, Glasgow, United Kingdom.

Abstract

Previous reports of altered grey and white matter structure in Major Depressive Disorder (MDD) have been inconsistent. Recent meta-analyses have, however, reported reduced hippocampal grey matter volume in MDD and reduced white matter integrity in several brain regions. The use of different diagnostic criteria, scanners and imaging sequences may, however, obscure further anatomical differences. In this study, we tested for differences in subcortical grey matter volume (n = 1157) and white matter integrity (n = 1089) between depressed individuals and controls in the subset of 8590 UK Biobank Imaging study participants who had undergone depression assessments. Whilst we found no significant differences in subcortical volumes, significant reductions were found in depressed individuals versus controls in global white matter integrity, as measured by fractional anisotropy (FA) (β = -0.182, p = 0.005). We also found reductions in FA in association/commissural fibres (β = -0.184, pcorrected = 0.010) and thalamic radiations (β = -0.159, pcorrected = 0.020). Tract-specific FA reductions were also found in the left superior longitudinal fasciculus (β = -0.194, pcorrected = 0.025), superior thalamic radiation (β = -0.224, pcorrected = 0.009) and forceps major (β = -0.193, pcorrected = 0.025) in depression (all betas standardised). Our findings provide further evidence for disrupted white matter integrity in MDD.

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center