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Gastroenterology. 2017 Sep;153(3):657-673.e1. doi: 10.1053/j.gastro.2017.07.007. Epub 2017 Jul 14.

The Evolving Genomic Landscape of Barrett's Esophagus and Esophageal Adenocarcinoma.

Author information

1
Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge, Cambridge, UK. Electronic address: gc502@mrc-cam.ac.uk.
2
Cancer Epidemiology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington.
3
Cancer Control, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
4
Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge, Cambridge, UK.

Abstract

We have recently gained unprecedented insight into genetic factors that determine risk for Barrett's esophagus (BE) and progression to esophageal adenocarcinoma (EA). Next-generation sequencing technologies have allowed us to identify somatic mutations that initiate BE and track genetic changes during development of tumors and invasive cancer. These technologies led to identification of mechanisms of tumorigenesis that challenge the current multistep model of progression to EA. Newer, cost-effective technologies create opportunities to rapidly translate the analysis of DNA into tools that can identify patients with BE at high risk for cancer, detect dysplastic lesions more reliably, and uncover mechanisms of carcinogenesis.

KEYWORDS:

Chromothripsis; Cytosponge; Esophagus; Genome-wide Association Study; Mutational Signature

PMID:
28716721
PMCID:
PMC6025803
DOI:
10.1053/j.gastro.2017.07.007
[Indexed for MEDLINE]
Free PMC Article

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