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Hum Immunol. 2017 Sep;78(9):574-581. doi: 10.1016/j.humimm.2017.07.005. Epub 2017 Jul 14.

Cytokine balance and behavioral intervention; findings from the Peer Approaches to Lupus Self-Management (PALS) project.

Author information

1
Department of Public Health Sciences, Medical University of South Carolina, 135 Cannon Street, Suite CS303, Charleston, SC 29425, USA. Electronic address: wiled@musc.edu.
2
Department of Public Health Sciences, Medical University of South Carolina, 135 Cannon Street, Suite CS303, Charleston, SC 29425, USA. Electronic address: hyerj@musc.edu.
3
Department of Public Health Sciences, Medical University of South Carolina, 135 Cannon Street, Suite CS303, Charleston, SC 29425, USA. Electronic address: ramakris@musc.edu.
4
Department of Public Health Sciences, Medical University of South Carolina, 135 Cannon Street, Suite CS303, Charleston, SC 29425, USA. Electronic address: faitht@musc.edu.
5
Department of Medicine, Medical College of Wisconsin, Clinical Cancer Center Building, 5th Floor, Suite C5400, 9200 W Wisconsin Ave, Milwaukee, WI 53226, USA. Electronic address: legede@mcw.edu.
6
Division of Rheumatology and Immunology, Medical University of South Carolina, 96 Jonathan Lucas St, Suite 8, Charleston, SC 29425, USA; Rheumatology Section, Medial Service, Ralph H. Johnson VA Medical Center, 109 Bee Street, Charleston, SC 29401, USA. Electronic address: oatesjc@musc.edu.
7
Division of Clinical Immunology and Allergy, University of Mississippi Medical Center, 2500 North State Street, N416, Jackson, MS 39216, USA. Electronic address: gmarshall@umc.edu.

Abstract

The Peer Approaches to Lupus Self-Management program sought to address the disparate impact of systemic lupus erythematosus (SLE) on African American women through a peer mentoring intervention with aims of reducing stress, anxiety, and depression. Given the association between psychological health and immune function this study examines the relationship between patient reported outcomes (PROs) in these domains and immunologic indicators of disease activity. Twenty-three African American women with SLE served as mentees in the intervention from whom PRO measures were collected at the outset, midpoint, and end of the 12week pilot study. Blood samples were collected pre- and post-intervention. Plasma was collected from the samples and cryopreserved for subsequent analyses. The strongest correlations were between the Generalized Anxiety Disorder measure and Th1/Th2 cytokine balance. Weaker correlations existed between depression and the Th1/Th2 cytokine balance. Assessment of fresh versus cryopreserved samples revealed that changes in Th1/Th2 cytokine balance within the intervention were generally equivalent, regardless of sample type. The PALS intervention resulted in significant improvements to anxiety and depression levels which were significantly associated with positive changes in Th1/Th2 cytokine balance indicating a possible underlying mechanism of action. The nature of this relationship warrants further study.

KEYWORDS:

African American; Behavioral intervention; Cytokines; Systemic Lupus Erythematosus; Women

PMID:
28716698
PMCID:
PMC6013837
DOI:
10.1016/j.humimm.2017.07.005
[Indexed for MEDLINE]
Free PMC Article

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