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Magn Reson Imaging. 2017 Nov;43:105-109. doi: 10.1016/j.mri.2017.07.014. Epub 2017 Jul 15.

Cancer recurrence monitoring using hyperpolarized [1-13C]pyruvate metabolic imaging in murine breast cancer model.

Author information

1
Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, CA, USA. Electronic address: peter.shin@ucsf.edu.
2
Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, CA, USA; The UC Berkeley - UCSF Graduate Program in Bioengineering, CA, USA.
3
Biomedical Sciences Graduate Program, University of California at San Francisco, San Francisco, CA, USA.
4
Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, CA, USA.
5
Department of Cell and Tissue Biology, University of California at San Francisco, San Francisco, CA, USA.
6
Biomedical Sciences Graduate Program, University of California at San Francisco, San Francisco, CA, USA; Department of Cell and Tissue Biology, University of California at San Francisco, San Francisco, CA, USA.

Abstract

The purpose of this work was to study the anatomic and metabolic changes that occur with tumor progression, regression and recurrence in a switchable MYC-driven murine breast cancer model. Serial 1H MRI and hyperpolarized [1-13C]pyruvate metabolic imaging were used to investigate the changes in tumor volume and glycolytic metabolism over time during the multistage tumorigenesis. We show that acute de-induction of MYC expression in established tumors results in rapid tumor regression and significantly reduced glycolytic metabolism as measured by pyruvate-to-lactate conversion. Moreover, cancer recurrences occurring at the tumor sites independently of MYC expression were observed to accompany markedly increased lactate production.

KEYWORDS:

Breast cancer; Cancer recurrence; Hyperpolarized (13)C MRI; Metabolic imaging

PMID:
28716678
PMCID:
PMC5632580
DOI:
10.1016/j.mri.2017.07.014
[Indexed for MEDLINE]
Free PMC Article

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